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Concurrent genome and epigenome editing by CRISPR-mediated sequence replacement

Abstract Background Recent advances in genome editing have facilitated the direct manipulation of not only the genome, but also the epigenome. Genome editing is typically performed by introducing a single CRISPR/Cas9-mediated double-strand break (DSB), followed by non-homologous end joining (NHEJ)-...

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Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Prif Awduron: Jes Alexander, Gregory M. Findlay, Martin Kircher, Jay Shendure
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: BMC 2019-11-01
Cyfres:BMC Biology
Pynciau:
Mynediad Ar-lein:http://link.springer.com/article/10.1186/s12915-019-0711-z
Tagiau: Ychwanegu Tag
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