Human TRIB2 Oscillates during the Cell Cycle and Promotes Ubiquitination and Degradation of CDC25C

Tribbles homolog 2 (TRIB2) is a member of the mammalian Tribbles family of serine/threonine pseudokinases (TRIB1-3). Studies of TRIB2 indicate that many of the molecular interactions between the single Drosophila Tribbles (Trbl) protein and interacting partners are evolutionary conserved. In this st...

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Bibliographic Details
Main Authors: Kai Ling Liang, Roberto Paredes, Ruaidhri Carmody, Patrick A. Eyers, Stefan Meyer, Tommie V. McCarthy, Karen Keeshan
Format: Artigo
Language:Inglês
Published: MDPI AG 2016-08-01
Series:International Journal of Molecular Sciences
Subjects:
TRIB2
pseudokinase
CDC25B
CDC25C
dual-specificity phosphatase
ubiquitin proteasome
degradation
cell cycle
Online Access:http://www.mdpi.com/1422-0067/17/9/1378
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