Blocking the PCNA/NKp44 Checkpoint to Stimulate NK Cell Responses to Multiple Myeloma

Multiple Myeloma (MM) is a devastating malignancy that evades immune destruction using multiple mechanisms. The NKp44 receptor interacts with PCNA (Proliferating Cell Nuclear Antigen) and may inhibit NK cells’ functions. Here we studied in vitro the expression and function of PCNA on MM cells. First...

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Main Authors: Muhammed Iraqi, Avishay Edri, Yariv Greenshpan, Oron Goldstein, Noa Ofir, Priyanka Bolel, Muhammad Abu Ahmad, Miri Zektser, Kerry S. Campbell, Ory Rouvio, Roi Gazit, Angel Porgador
Formato: Artigo
Idioma:Inglês
Publicado: MDPI AG 2022-04-01
Series:International Journal of Molecular Sciences
Assuntos:
multiple myeloma
PCNA
immune check point
NKp44
clones
Acceso en liña:https://www.mdpi.com/1422-0067/23/9/4717
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