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Critical structural and functional roles for the N-terminal insertion sequence in surfactant protein B analogs.
Surfactant protein B (SP-B; 79 residues) belongs to the saposin protein superfamily, and plays functional roles in lung surfactant. The disulfide cross-linked, N- and C-terminal domains of SP-B have been theoretically predicted to fold as charged, amphipathic helices, suggesting their participation...
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Main Authors: | , , , , , , , , , , |
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Format: | Artigo |
Sprog: | Inglês |
Udgivet: |
Public Library of Science (PLoS)
2010-01-01
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Serier: | PLoS ONE |
Online adgang: | http://europepmc.org/articles/PMC2805716?pdf=render |
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