High-dose N-acetylcysteine for long-term, regular treatment of early-stage chronic obstructive pulmonary disease (GOLD I–II): study protocol for a multicenter, double-blinded, parallel-group, randomized controlled trial in China

Abstract Introduction The presence of increased oxidative stress and airway inflammation has been proven in subjects with chronic obstructive pulmonary disease (COPD). Several studies have demonstrated that drugs with antioxidant and anti-inflammatory properties such as N-acetylcysteine (NAC) can re...

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Autori principali: Heshen Tian, Yumin Zhou, Longhui Tang, Fan Wu, Zhishan Deng, Bijia Lin, Peiyu Huang, Shaodan Wei, Dongxing Zhao, Jingping Zheng, Nanshan Zhong, Pixin Ran
Natura: Artigo
Lingua:Inglês
Pubblicazione: BMC 2020-09-01
Serie:Trials
Soggetti:
Chronic obstructive pulmonary disease
Spirometry
Acute exacerbation
High-dose N-acetylcysteine
Randomized controlled trial
Accesso online:http://link.springer.com/article/10.1186/s13063-020-04701-8
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