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Reverse engineering of drug induced DNA damage response signalling pathway reveals dual outcomes of ATM kinase inhibition

The DNA Damage Response (DDR) pathway represents a signalling mechanism that is activated in eukaryotic cells following DNA damage and comprises of proteins involved in DNA damage detection, DNA repair, cell cycle arrest and apoptosis. This pathway consists of an intricate network of signalling inte...

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Detalhes bibliográficos
Main Authors: Michael A. Idowu, Hilal S Khalil, James L. Bown, Nikolai Zhelev
Formato: Artigo
Idioma:Inglês
Publicado em: Pensoft Publishers 2013-12-01
Colecção:BioDiscovery
Assuntos:
ATM
Acesso em linha:https://biodiscovery.pensoft.net/article/8954/download/pdf/
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