Monitoring Autophagy Immunohistochemically and Ultrastructurally during Human Head and Neck Carcinogenesis. Relationship with the DNA Damage Response Pathway

Autophagy is a catabolic process that preserves cellular homeostasis. Its exact role during carcinogenesis is not completely defined. Specifically in head and neck cancer, such information from clinical settings that comprise the whole spectrum of human carcinogenesis is very limited. Towards this d...

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Main Authors: Sophia Havaki, Vassiliki Vlachou, Christos P. Zampetidis, Platonas Selemenakis, Athanassios Kotsinas, Eleni Mavrogonatou, Sophia V. Rizou, Euthymios Kyrodimos, Konstantinos Evangelou, Dimitris Kletsas, Alexandra Giatromanolaki, Vassilis G. Gorgoulis
Format: Artigo
Sprog:Inglês
Udgivet: MDPI AG 2017-09-01
Serier:International Journal of Molecular Sciences
Fag:
autophagy
Beclin-1
LC3B
p62
carcinogenesis
DNA damage response
Online adgang:https://www.mdpi.com/1422-0067/18/9/1920
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