Homeobox oncogene activation by pan-cancer DNA hypermethylation

Abstract Background Cancers have long been recognized to be not only genetically but also epigenetically distinct from their tissues of origin. Although genetic alterations underlying oncogene upregulation have been well studied, to what extent epigenetic mechanisms, such as DNA methylation, can als...

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Hlavní autoři: Jianzhong Su, Yung-Hsin Huang, Xiaodong Cui, Xinyu Wang, Xiaotian Zhang, Yong Lei, Jianfeng Xu, Xueqiu Lin, Kaifu Chen, Jie Lv, Margaret A. Goodell, Wei Li
Médium: Artigo
Jazyk:Inglês
Vydáno: BMC 2018-08-01
Edice:Genome Biology
Témata:
Pan-cancer analysis
DNA methylation
Whole-genome bisulfite sequencing
Gene-body
Hypermethylation
Transcription
On-line přístup:http://link.springer.com/article/10.1186/s13059-018-1492-3
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