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GlnR Dominates Rifamycin Biosynthesis by Activating the rif Cluster Genes Transcription Both Directly and Indirectly in Amycolatopsis mediterranei

Because of the remarkable efficacy in treating mycobacterial infections, rifamycin and its derivatives are still first-line antimycobacterial drugs. It has been intensely studied to increase rifamycin yield from Amycolatopsis mediterranei, and nitrate is found to provide a stable and remarkable stim...

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Main Authors: Xinqiang Liu, Yuanyuan Liu, Chao Lei, Guoping Zhao, Jin Wang
Format: Artigo
Jezik:Inglês
Izdano: Frontiers Media S.A. 2020-03-01
Serija:Frontiers in Microbiology
Teme:
Online dostop:https://www.frontiersin.org/article/10.3389/fmicb.2020.00319/full
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