1,2,4-Triazolo[1,5-<i>a</i>]pyrimidines as a Novel Class of Inhibitors of the HIV-1 Reverse Transcriptase-Associated Ribonuclease H Activity

Despite great efforts have been made in the prevention and therapy of human immunodeficiency virus (HIV-1) infection, however the difficulty to eradicate latent viral reservoirs together with the emergence of multi-drug-resistant strains require the search for innovative agents, possibly exploiting...

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Main Authors: Jenny Desantis, Serena Massari, Angela Corona, Andrea Astolfi, Stefano Sabatini, Giuseppe Manfroni, Deborah Palazzotti, Violetta Cecchetti, Christophe Pannecouque, Enzo Tramontano, Oriana Tabarrini
Formato: Artigo
Idioma:Inglês
Publicado: MDPI AG 2020-03-01
Series:Molecules
Assuntos:
hiv-1
rnase h
1,2,4-triazolo[1,5-<i>a</i>]pyrimidine
allosteric inhibitors
rt
aids
Acceso en liña:https://www.mdpi.com/1420-3049/25/5/1183
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