TFEB Probably Involved in Midazolam-Disturbed Lysosomal Homeostasis and Its Induced β-Amyloid Accumulation

Alzheimer’s disease (AD) is one of the most common neurodegenerative diseases, and β-amyloid (Aβ) plays a leading role in the pathogenesis of AD. The transcription factor EB (TFEB), a main regulating factor of autophagy and lysosome biosynthesis, is involved in the pathogenesis of AD by regulating a...

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Main Authors: Dan Cheng, Qilian Tan, Qianyun Zhu, Jiqian Zhang, Xiaoyu Han, Panpan Fang, Weilin Jin, Xuesheng Liu
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2019-05-01
Colecção:Frontiers in Human Neuroscience
Assuntos:
emotion
β-amyloid
lysosome
TFEB
midazolam
Acesso em linha:https://www.frontiersin.org/article/10.3389/fnhum.2019.00108/full
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