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Rac1-NADPH oxidase signaling promotes CD36 activation under glucotoxic conditions in pancreatic beta cells

We recently reported that cluster determinant 36 (CD36), a fatty acid transporter, plays a pivotal role in glucotoxicity-induced β-cell dysfunction. However, little is known about how glucotoxicity influences CD36 expression. Emerging evidence suggests that the small GTPase Rac1 is involved in the p...

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Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Prif Awduron: Suma Elumalai, Udayakumar Karunakaran, In Kyu Lee, Jun Sung Moon, Kyu Chang Won
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: Elsevier 2017-04-01
Cyfres:Redox Biology
Mynediad Ar-lein:http://www.sciencedirect.com/science/article/pii/S2213231716301720
Tagiau: Ychwanegu Tag
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