DAF-16 and TCER-1 Facilitate Adaptation to Germline Loss by Restoring Lipid Homeostasis and Repressing Reproductive Physiology in C. elegans.

Elimination of the proliferating germline extends lifespan in C. elegans. This phenomenon provides a unique platform to understand how complex metazoans retain metabolic homeostasis when challenged with major physiological perturbations. Here, we demonstrate that two conserved transcription regulato...

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Main Authors: Francis Raj Gandhi Amrit, Elizabeth Marie Steenkiste, Ramesh Ratnappan, Shaw-Wen Chen, T Brooke McClendon, Dennis Kostka, Judith Yanowitz, Carissa Perez Olsen, Arjumand Ghazi
Formato: Artigo
Idioma:Inglês
Publicado: Public Library of Science (PLoS) 2016-02-01
Series:PLoS Genetics
Acceso en liña:http://europepmc.org/articles/PMC4749232?pdf=render
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