Genetic Background of Polycythemia Vera

Polycythemia vera belongs to myeloproliferative neoplasms, essentially by affecting the erythroblastic lineage. JAK2 alterations have emerged as major driver mutations triggering PV-phenotype with the <i>V617F</i> mutation detected in nearly 98% of cases. That’s why JAK2 targeting therap...

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Main Authors: Mathilde Regimbeau, Romain Mary, François Hermetet, François Girodon
Formato: Artigo
Idioma:Inglês
Publicado: MDPI AG 2022-04-01
Series:Genes
Assuntos:
polycythemia vera
<i>JAK2</i> mutation
erythrocytosis
myeloproliferative neoplasm
mutational landscape
Acceso en liña:https://www.mdpi.com/2073-4425/13/4/637
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