Randomised controlled trial of ketamine augmentation of electroconvulsive therapy to improve neuropsychological and clinical outcomes in depression (Ketamine-ECT study)

Background: Electroconvulsive therapy (ECT) is the most effective acute treatment for severe depression, but there are concerns about its adverse cognitive effects. ECT may impair cognition through stimulation of glutamate receptors, and preliminary evidence has suggested that ketamine, a glutamate...

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Detalhes bibliográficos
Main Authors: Ian M Anderson, Andrew Blamire, Tim Branton, Sabrina Brigadoi, Ross Clark, Darragh Downey, Graham Dunn, Andrew Easton, Rebecca Elliott, Clare Elwell, Katherine Hayden, Fiona Holland, Salman Karim, Jo Lowe, Colleen Loo, Rajesh Nair, Timothy Oakley, Antony Prakash, Parveen K Sharma, Stephen R Williams, R Hamish McAllister-Williams
Formato: Artigo
Idioma:Inglês
Publicado em: NIHR Journals Library 2017-03-01
Colecção:Efficacy and Mechanism Evaluation
Assuntos:
electroconvulsive therapy
ketamine
depression
neuropsychological tests
functional near-infrared spectroscopy
patient survey
randomised controlled trial
Acesso em linha:https://doi.org/10.3310/eme04020
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