Preclinical effectiveness of selective inhibitor of IRS1/2 NT157 in osteosarcoma cell lines.

Osteosarcoma (OS) is the most common primary bone tumor in children and young adults. Several studies have confirmed the involvement of the IGF system in the regulation of OS cell proliferation and differentiation as well as in the protection of cells from chemotherapy. IRS-1 is a critical mediator...

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Bibliografiska uppgifter
Huvudupphovsmän: Cecilia eGarofalo, Mariantonietta eCapristo, Caterina eMancarella, Hadas eReuveni, Piero ePicci, Katia eScotlandi
Materialtyp: Artigo
Språk:Inglês
Publicerad: Frontiers Media S.A. 2015-05-01
Serie:Frontiers in Endocrinology
Ämnen:
Chemotherapy, Adjuvant
Sarcoma
osteosarcoma (OS)
IGF system and signaling
IRS-1
NT157
Länkar:http://journal.frontiersin.org/Journal/10.3389/fendo.2015.00074/full
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