Preclinical effectiveness of selective inhibitor of IRS1/2 NT157 in osteosarcoma cell lines.

Osteosarcoma (OS) is the most common primary bone tumor in children and young adults. Several studies have confirmed the involvement of the IGF system in the regulation of OS cell proliferation and differentiation as well as in the protection of cells from chemotherapy. IRS-1 is a critical mediator...

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Bibliografische gegevens
Hoofdauteurs: Cecilia eGarofalo, Mariantonietta eCapristo, Caterina eMancarella, Hadas eReuveni, Piero ePicci, Katia eScotlandi
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: Frontiers Media S.A. 2015-05-01
Reeks:Frontiers in Endocrinology
Onderwerpen:
Chemotherapy, Adjuvant
Sarcoma
osteosarcoma (OS)
IGF system and signaling
IRS-1
NT157
Online toegang:http://journal.frontiersin.org/Journal/10.3389/fendo.2015.00074/full
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