Preclinical effectiveness of selective inhibitor of IRS1/2 NT157 in osteosarcoma cell lines.

Osteosarcoma (OS) is the most common primary bone tumor in children and young adults. Several studies have confirmed the involvement of the IGF system in the regulation of OS cell proliferation and differentiation as well as in the protection of cells from chemotherapy. IRS-1 is a critical mediator...

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Bibliografski detalji
Glavni autori: Cecilia eGarofalo, Mariantonietta eCapristo, Caterina eMancarella, Hadas eReuveni, Piero ePicci, Katia eScotlandi
Format: Artigo
Jezik:Inglês
Izdano: Frontiers Media S.A. 2015-05-01
Serija:Frontiers in Endocrinology
Teme:
Chemotherapy, Adjuvant
Sarcoma
osteosarcoma (OS)
IGF system and signaling
IRS-1
NT157
Online pristup:http://journal.frontiersin.org/Journal/10.3389/fendo.2015.00074/full
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