Adoptive immunotherapy with haploidentical natural killer cells and Anti-GD2 monoclonal antibody m3F8 for resistant neuroblastoma: Results of a phase I study

Natural killer (NK) cell-mediated antibody-dependent toxicity is a potent mechanism of action of the anti-GD2 murine monoclonal antibody 3F8 (m3F8). Killer immunoglobulin-like receptor (KIR) and HLA genotypes modulate NK activity and are key prognostic markers in m3F8-treated patients with neuroblas...

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Main Authors: Shakeel Modak, Jean-Benoit Le Luduec, Irene Y. Cheung, Debra A. Goldman, Irina Ostrovnaya, Ekaterina Doubrovina, Ellen Basu, Brian H. Kushner, Kim Kramer, Stephen S. Roberts, Richard J. O'Reilly, Nai-Kong V. Cheung, Katharine C. Hsu
格式: Artigo
語言:Inglês
出版: Taylor & Francis Group 2018-08-01
叢編:OncoImmunology
主題:
adoptive immunotherapy
m3f8
neuroblastoma
nk cells
在線閱讀:http://dx.doi.org/10.1080/2162402X.2018.1461305
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