Essential Role for CD30-Transglutaminase 2 Axis in Memory Th1 and Th17 Cell Generation

Memory helper T (Th) cells are crucial for secondary immune responses against infectious microorganisms but also drive the pathogenesis of chronic inflammatory diseases. Therefore, it is of fundamental importance to understand how memory T cells are generated. However, the molecular mechanisms gover...

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Bibliographic Details
Main Authors: Akane S. Suzuki, Ryoji Yagi, Motoko Y. Kimura, Chiaki Iwamura, Kenta Shinoda, Atsushi Onodera, Kiyoshi Hirahara, Damon J. Tumes, Ryo Koyama-Nasu, Siiri E. Iismaa, Robert M. Graham, Shinichiro Motohashi, Toshinori Nakayama
Format: Artigo
Language:Inglês
Published: Frontiers Media S.A. 2020-07-01
Series:Frontiers in Immunology
Subjects:
TG2
CD30
memory Th cell generation
Th17
Th1
memory precursor
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2020.01536/full
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