Alzheimer-specific variants in the 3'UTR of Amyloid precursor protein affect microRNA function

<p>Abstract</p> <p>Background</p> <p>APP expression misregulation can cause genetic Alzheimer's disease (AD). Recent evidences support the hypothesis that polymorphisms located in microRNA (miRNA) target sites could influence the risk of developing neurodegenerativ...

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Hauptverfasser: Calon Frédéric, Delay Charlotte, Mathews Paul, Hébert Sébastien S
Format: Artigo
Sprache:Inglês
Veröffentlicht: BMC 2011-10-01
Schriftenreihe:Molecular Neurodegeneration
Schlagworte:
Amyloid precursor protein
microRNA, single nucleotide polymorphism
Alzheimer's disease
miR-147, miR-20a
Online Zugang:http://www.molecularneurodegeneration.com/content/6/1/70
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