Langerhans Cells From Mice at Birth Express Endocytic- and Pattern Recognition-Receptors, Migrate to Draining Lymph Nodes Ferrying Antigen and Activate Neonatal T Cells in vivo

Antigen capturing at the periphery is one of the earliest, crucial functions of antigen-presenting cells (APCs) to initiate immune responses. Langerhans cells (LCs), the epidermal APCs migrate to draining lymph nodes (DLNs) upon acquiring antigens. An arsenal of endocytic molecules is available to t...

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Main Authors: Miguel Angel Becerril-García, Juan Carlos Yam-Puc, Raúl Maqueda-Alfaro, Nonantzin Beristain-Covarrubias, Monica Heras-Chavarría, Isis Amara Gallegos-Hernández, Juana Calderón-Amador, Rosario Munguía-Fuentes, Luis Donis-Maturano, Adriana Flores-Langarica, Leopoldo Flores-Romo
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2020-04-01
Colecção:Frontiers in Immunology
Assuntos:
neonates
immunization at birth
T cell activation
in vivo immune response
CD204
CD14
Acesso em linha:https://www.frontiersin.org/article/10.3389/fimmu.2020.00744/full
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