Studying Brugada Syndrome With an SCN1B Variants in Human-Induced Pluripotent Stem Cell-Derived Cardiomyocytes

BackgroundAmong rare channelopathies BrS patients are at high risk of sudden cardiac death (SCD). SCN5A mutations are found in a quarter of patients. Other rare gene mutations including SCN1B have been implicated to BrS. Studying the human cellular phenotype of BrS associated with rare gene mutation...

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Main Authors: Ibrahim El-Battrawy, Jonas Müller, Zhihan Zhao, Lukas Cyganek, Rujia Zhong, Feng Zhang, Mandy Kleinsorge, Huan Lan, Xin Li, Qiang Xu, Mengying Huang, Zhenxing Liao, Alexander Moscu-Gregor, Sebastian Albers, Hendrik Dinkel, Siegfried Lang, Sebastian Diecke, Wolfram-Hubertus Zimmermann, Jochen Utikal, Thomas Wieland, Martin Borggrefe, Xiaobo Zhou, Ibrahim Akin
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2019-11-01
Colecção:Frontiers in Cell and Developmental Biology
Assuntos:
Brugada
sudden cardiac death
channelopathy
genetic
sodium channel
Acesso em linha:https://www.frontiersin.org/article/10.3389/fcell.2019.00261/full
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