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Lipidomic analysis links mycobactin synthase K to iron uptake and virulence in M. tuberculosis.

The prolonged survival of Mycobacterium tuberculosis (M. tb) in the host fundamentally depends on scavenging essential nutrients from host sources. M. tb scavenges non-heme iron using mycobactin and carboxymycobactin siderophores, synthesized by mycobactin synthases (Mbt). Although a general mechani...

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Detalhes bibliográficos
Main Authors: Cressida A Madigan, Amanda Jezek Martinot, Jun-Rong Wei, Ashoka Madduri, Tan-Yun Cheng, David C Young, Emilie Layre, Jeffrey P Murry, Eric J Rubin, D Branch Moody
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science (PLoS) 2015-03-01
Colecção:PLoS Pathogens
Acesso em linha:http://europepmc.org/articles/PMC4376628?pdf=render
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