The Pathophysiological Role of Microglia in Dynamic Surveillance, Phagocytosis and Structural Remodeling of the Developing CNS

In vertebrates, during an early wave of hematopoiesis in the yolk sac between embryonic day E7.0 and E9.0, cells of mesodermal leaflet addressed to macrophage lineage enter in developing central nervous system (CNS) and originate the developing native microglial cells. Depending on the species, micr...

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Bibliographic Details
Main Authors: Cataldo Arcuri, Carmen Mecca, Roberta Bianchi, Ileana Giambanco, Rosario Donato
Format: Artigo
Language:Inglês
Published: Frontiers Media S.A. 2017-06-01
Series:Frontiers in Molecular Neuroscience
Subjects:
immunosurveillance
microglia phagocytosis
synaptic pruning
autism spectrum disorders
Nasu-Hakola disease
Rett syndrome
Online Access:http://journal.frontiersin.org/article/10.3389/fnmol.2017.00191/full
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