Mice lacking the circadian modulators SHARP1 and SHARP2 display altered sleep and mixed state endophenotypes of psychiatric disorders.

Increasing evidence suggests that clock genes may be implicated in a spectrum of psychiatric diseases, including sleep and mood related disorders as well as schizophrenia. The bHLH transcription factors SHARP1/DEC2/BHLHE41 and SHARP2/DEC1/BHLHE40 are modulators of the circadian system and SHARP1/DEC...

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Auteurs principaux: Paul C Baier, Magdalena M Brzózka, Ali Shahmoradi, Lisa Reinecke, Christina Kroos, Sven P Wichert, Henrik Oster, Michael C Wehr, Reshma Taneja, Johannes Hirrlinger, Moritz J Rossner
Format: Artigo
Langue:Inglês
Publié: Public Library of Science (PLoS) 2014-01-01
Collection:PLoS ONE
Accès en ligne:http://europepmc.org/articles/PMC4207740?pdf=render
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