The Functional Role of Voltage-Gated Sodium Channel Nav1.5 in Metastatic Breast Cancer

Voltage-gated sodium channels (VGSCs), which are abnormally expressed in various types of cancers such as breast cancer, prostate cancer, lung cancer, and cervical cancer, are involved in the metastatic process of invasion and migration. Nav1.5 is a pore-forming α subunit of VGSC encoded by SCN5A. V...

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Detalhes bibliográficos
Main Authors: Qianxuan Luo, Ting Wu, Wenfang Wu, Gong Chen, Xuan Luo, Liping Jiang, Huai Tao, Mingqiang Rong, Shuntong Kang, Meichun Deng
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2020-07-01
Colecção:Frontiers in Pharmacology
Assuntos:
VGSCs
Nav1.5
breast cancer
metastasis
mechanism
inhibitors
Acesso em linha:https://www.frontiersin.org/article/10.3389/fphar.2020.01111/full
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