Effects of Toll-like receptor antagonist 4,5-dihydro-3-phenyl-5-isoxasole acetic acid on the progression of kidney disease in mice on a high-fat diet

Background: Obesity-related metabolic disorders are closely associated with inflammation induced by innate immunity. Toll-like receptors (TLRs) play a pivotal role in the innate immune system by activating proinflammatory signaling pathways. GIT27 (4,5-dihydro-3-phenyl-5-isoxasole acetic acid) is an...

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Hlavní autoři: Hye Sook Min, Jung Eun Kim, Mi Hwa Lee, Hye Kyoung Song, Mi Jin Lee, Ji Eun Lee, Hyun Wook Kim, Jin Joo Cha, Young Youl Hyun, Jee Young Han, Dae Ryong Cha, Young Sun Kang
Médium: Artigo
Jazyk:Inglês
Vydáno: The Korean Society of Nephrology 2014-03-01
Edice:Kidney Research and Clinical Practice
Témata:
Kidney disease
Metabolic syndrome
Obesity
Toll-like receptors
On-line přístup:http://www.sciencedirect.com/science/article/pii/S2211913213000983
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