Osteopontin Deficiency Suppresses Intestinal Tumor Development in Apc-Deficient Min Mice

Osteopontin (OPN) is a secreted phosphoglycoprotein, and is a transcriptional target of aberrant Wnt signaling. OPN is upregulated in human colon cancers, and is suggested to enhance cancer progression. In this study, the effect of deficiency of OPN on intestinal tumor development in Apc-deficient M...

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Autori principali: Rikako Ishigamori, Masami Komiya, Shinji Takasu, Michihiro Mutoh, Toshio Imai, Mami Takahashi
Natura: Artigo
Lingua:Inglês
Pubblicazione: MDPI AG 2017-05-01
Serie:International Journal of Molecular Sciences
Soggetti:
osteopontin
colorectal tumor
macrophage
Accesso online:http://www.mdpi.com/1422-0067/18/5/1058
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