Impaired mesocorticolimbic connectivity underlies increased pain sensitivity in chronic low back pain

Chronic low back pain (cLBP) is a prevalent disorder. A growing body of evidence linking the pathology of the reward network to chronic pain suggests that pain sensitization may contribute to cLBP chronification via disruptions of mesocortical and mesolimbic circuits in the reward system. Resting-st...

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Main Authors: Siyi Yu, Wen Li, Wei Shen, Robert R. Edwards, Randy L. Gollub, Georgia Wilson, Joel Park, Ana Ortiz, Jin Cao, Jessica Gerber, Ishtiaq Mawla, Suk-Tak Chan, Jeungchan Lee, Ajay D. Wasan, Vitaly Napadow, Ted J. Kaptchuk, Bruce Rosen, Jian Kong
Format: Artigo
Sprog:Inglês
Udgivet: Elsevier 2020-09-01
Serier:NeuroImage
Fag:
Low back pain
Central sensitization
Pain sensitivity
Quantitative sensory testing
Mesocorticolimbic network
Reward network
Online adgang:http://www.sciencedirect.com/science/article/pii/S1053811920304559
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