Tuberculosis Exacerbates HIV-1 Infection through IL-10/STAT3-Dependent Tunneling Nanotube Formation in Macrophages

Summary: The tuberculosis (TB) bacillus, Mycobacterium tuberculosis (Mtb), and HIV-1 act synergistically; however, the mechanisms by which Mtb exacerbates HIV-1 pathogenesis are not well known. Using in vitro and ex vivo cell culture systems, we show that human M(IL-10) anti-inflammatory macrophages...

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Main Authors: Shanti Souriant, Luciana Balboa, Maeva Dupont, Karine Pingris, Denise Kviatcovsky, Céline Cougoule, Claire Lastrucci, Aicha Bah, Romain Gasser, Renaud Poincloux, Brigitte Raynaud-Messina, Talal Al Saati, Sandra Inwentarz, Susana Poggi, Eduardo Jose Moraña, Pablo González-Montaner, Marcelo Corti, Bernard Lagane, Isabelle Vergne, Carolina Allers, Deepak Kaushal, Marcelo J. Kuroda, Maria del Carmen Sasiain, Olivier Neyrolles, Isabelle Maridonneau-Parini, Geanncarlo Lugo-Villarino, Christel Vérollet
Format: Artigo
Language:Inglês
Published: Elsevier 2019-03-01
Series:Cell Reports
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124719302773
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