Tuberculosis exacerbates HIV-1 infection through IL-10/STAT3-dependent tunneling nanotube formation in macrophages

The tuberculosis (TB) bacillus, Mycobacterium tuberculosis (Mtb), and HIV-1 act synergistically; however, the mechanisms by which Mtb exacerbates HIV-1 pathogenesis are not well known. Using in vitro and ex vivo cell culture systems, we show that human M(IL-10) anti-inflammatory macrophages, present...

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Publicado no:Cell Rep
Main Authors: Souriant, Shanti, Balboa, Luciana, Dupont, Maeva, Pingris, Karine, Kviatcovsky, Denise, Cougoule, Céline, Lastrucci, Claire, Bah, Aicha, Gasser, Romain, Poincloux, Renaud, Raynaud-Messina, Brigitte, Saati, Talal Al, Inwentarz, Sandra, Poggi, Susana, Moraña, Eduardo Jose, González-Montaner, Pablo, Corti, Marcelo, Lagane, Bernard, Vergne, Isabelle, Allers, Carolina, Kaushal, Deepak, Kuroda, Marcelo J., Sasiain, Maria del Carmen, Neyrolles, Olivier, Maridonneau-Parini, Isabelle, Lugo-Villarino, Geanncarlo, Vérollet, Christel
Formato: Artigo
Idioma:Inglês
Publicado em: 2019
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6733268/
https://ncbi.nlm.nih.gov/pubmed/30917314
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2019.02.091
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