Systematic Characterization of Recurrent Genomic Alterations in Cyclin-Dependent Kinases Reveals Potential Therapeutic Strategies for Cancer Treatment

Summary: Recurrent copy-number alterations, mutations, and transcript fusions of the genes encoding CDKs/cyclins are characterized in >10,000 tumors. Genomic alterations of CDKs/cyclins are dominantly driven by copy number aberrations. In contrast to cell-cycle-related CDKs/cyclins, which are glo...

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Main Authors: Weiwei Shan, Jiao Yuan, Zhongyi Hu, Junjie Jiang, Yueying Wang, Nicki Loo, Lingling Fan, Zhaoqing Tang, Tianli Zhang, Mu Xu, Yutian Pan, Jiaqi Lu, Meixiao Long, Janos L. Tanyi, Kathleen T. Montone, Yi Fan, Xiaowen Hu, Youyou Zhang, Lin Zhang
Formato: Artigo
Idioma:Inglês
Publicado: Elsevier 2020-07-01
Series:Cell Reports
Assuntos:
genomic alteration
cyclin-dependent kinase
cancer
CDK7 inhibitor
PARP inhibitor
combination therapy
Acceso en liña:http://www.sciencedirect.com/science/article/pii/S2211124720308652
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