Doxycycline regulated induction of AKT in murine prostate drives proliferation independently of p27 cyclin dependent kinase inhibitor downregulation.

The PI3 kinase/AKT pathway has been shown to increase degradation of the p27 cyclin dependent kinase inhibitor through phosphorylation of consensus AKT sites on p27 and SKP2, and AKT driven proliferation may be checked by feedback mechanisms that increase p27 expression and induce senescence. Howeve...

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מידע ביבליוגרפי
Main Authors: Hongyun Wang, Youyuan Xu, Zi Fang, Sen Chen, Steven P Balk, Xin Yuan
פורמט: Artigo
שפה:Inglês
יצא לאור: Public Library of Science (PLoS) 2012-01-01
סדרה:PLoS ONE
גישה מקוונת:http://europepmc.org/articles/PMC3402521?pdf=render
תגים: הוספת תג
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