Obatoclax, a Pan-BCL-2 Inhibitor, Downregulates Survivin to Induce Apoptosis in Human Colorectal Carcinoma Cells Via Suppressing WNT/β-catenin Signaling

Colorectal cancer (CRC) is a highly prevailing cancer and the fourth leading cause of cancer mortality worldwide. Aberrant expression of antiapoptotic BCL-2 family proteins is closely linked to neoplastic progression and chemoresistance. Obatoclax is a clinically developed drug, which binds antiapop...

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Main Authors: Chi-Hung R. Or, Chiao-Wen Huang, Ching-Chin Chang, You-Chen Lai, Yi-Ju Chen, Chia-Che Chang
Format: Artigo
Jezik:Inglês
Izdano: MDPI AG 2020-03-01
Serija:International Journal of Molecular Sciences
Teme:
obatoclax
survivin
wnt/β-catenin
apoptosis
colorectal cancer
Online dostop:https://www.mdpi.com/1422-0067/21/5/1773
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