Enhancement of oral bioavailability and anti-Parkinsonian efficacy of resveratrol through a nanocrystal formulation

Resveratrol (RES), a non-flavonoid polyphenol extracted from a wide variety of plants, exhibits neuroprotective activities against Parkinson's disease (PD). However, undesirable water solubility of RES reduces its oral bioavailability and demonstrates low efficacy in blood and brain, thus limit...

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Bibliographic Details
Main Authors: Sha Xiong, Wei Liu, Yile Zhou, Yousheng Mo, Yao Liu, Xiaojia Chen, Huafeng Pan, Dongsheng Yuan, Qi Wang, Tongkai Chen
Format: Artigo
Language:Inglês
Published: Elsevier 2020-07-01
Series:Asian Journal of Pharmaceutical Sciences
Subjects:
Nanocrystals
Resveratrol
Oral absorption
Brain permeability
Anti-Parkinsonian efficacy
Online Access:http://www.sciencedirect.com/science/article/pii/S1818087618313230
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