Physical Interactions and Expression Quantitative Traits Loci Identify Regulatory Connections for Obesity and Type 2 Diabetes Associated SNPs

The mechanisms that underlie the association between obesity and type 2 diabetes are not fully understood. Here, we investigated the role of the 3D genome organization in the pathogeneses of obesity and type-2 diabetes. We interpreted the combined and differential impacts of 196 diabetes and 390 obe...

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Hlavní autoři: Tayaza Fadason, Cameron Ekblad, John R. Ingram, William S. Schierding, Justin M. O'Sullivan
Médium: Artigo
Jazyk:Inglês
Vydáno: Frontiers Media S.A. 2017-10-01
Edice:Frontiers in Genetics
Témata:
Obesity and type-2 diabetes co-morbidity
spatial gene regulation
eQTLs
GWAS risk variants
Hi-C
On-line přístup:http://journal.frontiersin.org/article/10.3389/fgene.2017.00150/full
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