Randomised controlled trial of simvastatin treatment for autism in young children with neurofibromatosis type 1 (SANTA)

Abstract Background Neurofibromatosis 1 (NF1) is a monogenic model for syndromic autism. Statins rescue the social and cognitive phenotype in animal knockout models, but translational trials with subjects > 8 years using cognition/behaviour outcomes have shown mixed results. This trial breaks new...

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Detalhes bibliográficos
Main Authors: Stavros Stivaros, Shruti Garg, Maria Tziraki, Ying Cai, Owen Thomas, Joseph Mellor, Andrew A. Morris, Carly Jim, Karolina Szumanska-Ryt, Laura M Parkes, Hamied A. Haroon, Daniela Montaldi, Nicholas Webb, John Keane, Francisco X. Castellanos, Alcino J. Silva, Sue Huson, Stephen Williams, D. Gareth Evans, Richard Emsley, Jonathan Green, SANTA Consortium
Formato: Artigo
Idioma:Inglês
Publicado em: BMC 2018-02-01
Colecção:Molecular Autism
Assuntos:
Autism
Neurofibromatosis type 1
Neuroimaging
Randomised controlled trial
Statin
Simvastatin
Acesso em linha:http://link.springer.com/article/10.1186/s13229-018-0190-z
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