Characterization of nasal potential difference in cftr knockout and F508del-CFTR mice.

BACKGROUND: Treatments designed to correct cystic fibrosis transmembrane conductance regulator (CFTR) defects must first be evaluated in preclinical experiments in the mouse model of cystic fibrosis (CF). Mice nasal mucosa mimics the bioelectric defect seen in humans. The use of nasal potential diff...

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Main Authors: Emilie Lyne Saussereau, Delphine Roussel, Siradiou Diallo, Laurent Debarbieux, Aleksander Edelman, Isabelle Sermet-Gaudelus
Format: Artigo
Sprog:Inglês
Udgivet: Public Library of Science (PLoS) 2013-01-01
Serier:PLoS ONE
Online adgang:http://europepmc.org/articles/PMC3591431?pdf=render
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