RNF7 inhibits apoptosis and sunitinib sensitivity and promotes glycolysis in renal cell carcinoma via the SOCS1/JAK/STAT3 feedback loop

Abstract Background RING finger protein 7 (RNF7) is a highly conserved protein that functions as an E3 ubiquitin ligase. RNF7 overexpression is indicated in multiple human cancers, but its role in renal cell carcinoma (RCC) and the mechanisms underlying how it regulates the initiation and progressio...

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Principais autores: Chengwu Xiao, Wei Zhang, Meimian Hua, Huan Chen, Bin Yang, Ye Wang, Qing Yang
Formato: Artigo
Idioma:Inglês
Publicado em: BMC 2022-05-01
coleção:Cellular & Molecular Biology Letters
Assuntos:
Apoptosis
Clear cell renal cell carcinoma
Glycolysis
JAK/STAT3
RNF7
SOCS1
Acesso em linha:https://doi.org/10.1186/s11658-022-00337-5
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