Inhibition of phosphodiesterase 4 reduces ethanol intake and preference in C57BL/6J mice

Some anti-inflammatory medications reduce alcohol consumption in rodent models. Inhibition of phosphodiesterases (PDE) increases cAMP and reduces inflammatory signaling. Rolipram, an inhibitor of PDE4, markedly reduced ethanol intake and preference in mice and reduced ethanol seeking and consumption...

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Autori principali: Yuri A. Blednov, Jillian M. Benavidez, Mendy eBlack, R. Adron eHarris
Natura: Artigo
Lingua:Inglês
Pubblicazione: Frontiers Media S.A. 2014-05-01
Serie:Frontiers in Neuroscience
Soggetti:
Milrinone
Rolipram
alcohol
vinpocetine
two-bottle choice
PDE inhibitors
Accesso online:http://journal.frontiersin.org/Journal/10.3389/fnins.2014.00129/full
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