Inhibition of phosphodiesterase 4 reduces ethanol intake and preference in C57BL/6J mice

Some anti-inflammatory medications reduce alcohol consumption in rodent models. Inhibition of phosphodiesterases (PDE) increases cAMP and reduces inflammatory signaling. Rolipram, an inhibitor of PDE4, markedly reduced ethanol intake and preference in mice and reduced ethanol seeking and consumption...

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Bibliographic Details
Main Authors: Yuri A. Blednov, Jillian M. Benavidez, Mendy eBlack, R. Adron eHarris
Format: Artigo
Language:Inglês
Published: Frontiers Media S.A. 2014-05-01
Series:Frontiers in Neuroscience
Subjects:
Milrinone
Rolipram
alcohol
vinpocetine
two-bottle choice
PDE inhibitors
Online Access:http://journal.frontiersin.org/Journal/10.3389/fnins.2014.00129/full
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