Evaluation of Potential DnaK Modulating Proline-Rich Antimicrobial Peptides Identified by Computational Screening

The day is rapidly approaching where current antibiotic therapies will no longer be effective due to the development of multi-drug resistant bacteria. Antimicrobial peptides (AMPs) are a promising class of therapeutic agents which have the potential to help address this burgeoning problem. Proline-r...

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Main Authors: Thomas N. G. Handley, Wenyi Li, Nicholas G. Welch, Neil M. O’Brien-Simpson, Mohammed Akhter Hossain, John D. Wade
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2022-04-01
Colecção:Frontiers in Chemistry
Assuntos:
PrAMP
antibacterial peptides
DnaK inhibition
in silico
solid phase peptide synthesis
Acesso em linha:https://www.frontiersin.org/articles/10.3389/fchem.2022.875233/full
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