The Chemical Chaperone Proline Relieves the Thermosensitivity of a dnaK Deletion Mutant at 42°C

Since, like other osmolytes, proline can act as a protein stabilizer, we investigated the thermoprotectant properties of proline in vitro and in vivo. In vivo, elevated proline pools in Escherichia coli (obtained by altering the feedback inhibition by proline of γ-glutamylkinase, the first enzyme of...

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Detalhes bibliográficos
Main Authors: Chattopadhyay, Madhab K., Kern, Renée, Mistou, Michel-Yves, Dandekar, Abhaya M., Uratsu, Sandra L., Richarme, Gilbert
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2004
Assuntos:
Genetics and Molecular Biology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC529083/
https://ncbi.nlm.nih.gov/pubmed/15547289
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JB.186.23.8149-8152.2004
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