Targeting Glioblastoma Stem Cells with 2-Deoxy-D-Glucose (2-DG) Potentiates Radiation-Induced Unfolded Protein Response (UPR)

Glioblastoma (GBM) is the most common and aggressive primary brain tumor in adults, and despite optimized treatment options, median survival remains dismal. Contemporary evidence suggests disease recurrence results from expansion of a robustly radioresistant subset of GBM progenitor cells, termed GB...

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Detalhes bibliográficos
Main Authors: Sumedh S. Shah, Gregor A. Rodriguez, Alexis Musick, Winston M. Walters, Nicolas de Cordoba, Eric Barbarite, Megan M. Marlow, Brian Marples, Jeffrey S. Prince, Ricardo J. Komotar, Steven Vanni, Regina M. Graham
Formato: Artigo
Idioma:Inglês
Publicado em: MDPI AG 2019-01-01
Colecção:Cancers
Assuntos:
cancer stem cells
ER stress
glioblastoma multiforme
radiation
unfolded protein response
autophagy
Acesso em linha:https://www.mdpi.com/2072-6694/11/2/159
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