DOTA-functionalized polylysine: a high number of DOTA chelates positively influences the biodistribution of enzymatic conjugated anti-tumor antibody chCE7agl.

Site-specific enzymatic reactions with microbial transglutaminase (mTGase) lead to a homogenous species of immunoconjugates with a defined ligand/antibody ratio. In the present study, we have investigated the influence of different numbers of 1,4,7,10-tetraazacyclododecane-N-N'-N''-N&...

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Detalhes bibliográficos
Main Authors: Jürgen Grünberg, Simone Jeger, Dikran Sarko, Patrick Dennler, Kurt Zimmermann, Walter Mier, Roger Schibli
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science (PLoS) 2013-01-01
Colecção:PLoS ONE
Acesso em linha:http://europepmc.org/articles/PMC3614955?pdf=render
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