Maackiain Ameliorates 6-Hydroxydopamine and <i>SNCA</i> Pathologies by Modulating the PINK1/Parkin Pathway in Models of Parkinson’s Disease in <i>Caenorhabditis elegans</i> and the SH-SY5Y Cell Line

The movement disorder Parkinson’s disease (PD) is the second most frequently diagnosed neurodegenerative disease, and is associated with aging, the environment, and genetic factors. The intracellular aggregation of α-synuclein and the loss of dopaminergic neurons in the substantia nigra pars compact...

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Главные авторы: Rong-Tzong Tsai, Chia-Wen Tsai, Shih-Ping Liu, Jia-Xin Gao, Yun-Hua Kuo, Pei-Min Chao, Huey-Shan Hung, Woei-Cherng Shyu, Shinn-Zong Lin, Ru-Huei Fu
Формат: Artigo
Язык:Inglês
Опубликовано: MDPI AG 2020-06-01
Серии:International Journal of Molecular Sciences
Предметы:
Parkinson’s disease
maackiain
6-Hydroxydopamine
α-Synuclein
<i>Caenorhabditis elegans</i>
SH-SY5Y cell
Online-ссылка:https://www.mdpi.com/1422-0067/21/12/4455
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