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Dexmedetomidine Can Enhance PINK1/Parkin-Mediated Mitophagy in MPTP-Induced PD Mice Model by Activating AMPK

Parkinson’s disease (PD) is a common neurodegenerative disease characterized by the degeneration of dopaminergic (DA) neurons in the substantia nigra (SN). Our previous study has shown that dexmedetomidine (Dex) can protect mitochondrial function and reduce apoptosis in MPP+-induced SH-SY5Y cells. E...

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Bibliografske podrobnosti
Main Authors: Cheng Chen, Yaohua Chen, Tingting Liu, Dan Song, Di Ma, Oumei Cheng
Format: Artigo
Jezik:Inglês
Izdano: Hindawi Limited 2022-01-01
Serija:Oxidative Medicine and Cellular Longevity
Online dostop:http://dx.doi.org/10.1155/2022/7511393
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