FREQ-Seq: a rapid, cost-effective, sequencing-based method to determine allele frequencies directly from mixed populations.

Understanding evolutionary dynamics within microbial populations requires the ability to accurately follow allele frequencies through time. Here we present a rapid, cost-effective method (FREQ-Seq) that leverages Illumina next-generation sequencing for localized, quantitative allele frequency detect...

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Bibliografiska uppgifter
Huvudupphovsmän: Lon M Chubiz, Ming-Chun Lee, Nigel F Delaney, Christopher J Marx
Materialtyp: Artigo
Språk:Inglês
Publicerad: Public Library of Science (PLoS) 2012-01-01
Serie:PLoS ONE
Länkar:http://europepmc.org/articles/PMC3485326?pdf=render
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