rDNA Chromatin Activity Status as a Biomarker of Sensitivity to the RNA Polymerase I Transcription Inhibitor CX-5461

Hyperactivation of RNA polymerase I (Pol I) transcription of ribosomal RNA (rRNA) genes (rDNA) is a key determinant of growth and proliferation and a consistent feature of cancer cells. We have demonstrated that inhibition of rDNA transcription by the Pol I transcription inhibitor CX-5461 selectivel...

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Auteurs principaux: Jinbae Son, Katherine M. Hannan, Gretchen Poortinga, Nadine Hein, Donald P. Cameron, Austen R. D. Ganley, Karen E. Sheppard, Richard B. Pearson, Ross D. Hannan, Elaine Sanij
Format: Artigo
Langue:Inglês
Publié: Frontiers Media S.A. 2020-07-01
Collection:Frontiers in Cell and Developmental Biology
Sujets:
RNA polymerase I
CX-5461
ovarian cancer
DNA damage response
rDNA copy number
Accès en ligne:https://www.frontiersin.org/article/10.3389/fcell.2020.00568/full
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